![Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene | British Journal of Cancer Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene | British Journal of Cancer](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fsj.bjc.6600208/MediaObjects/41416_2002_Article_BF6600208_Fig1_HTML.gif)
Reduced 5-FU clearance in a patient with low DPD activity due to heterozygosity for a mutant allele of the DPYD gene | British Journal of Cancer
![Cost Implications of Reactive Versus Prospective Testing for Dihydropyrimidine Dehydrogenase Deficiency in Patients With Colorectal Cancer: A Single-Institution Experience - Con Murphy, Stephen Byrne, Gul Ahmed, Andrew Kenny, James Gallagher, Harry Harvey, Cost Implications of Reactive Versus Prospective Testing for Dihydropyrimidine Dehydrogenase Deficiency in Patients With Colorectal Cancer: A Single-Institution Experience - Con Murphy, Stephen Byrne, Gul Ahmed, Andrew Kenny, James Gallagher, Harry Harvey,](https://journals.sagepub.com/cms/10.1177/1559325818803042/asset/images/large/10.1177_1559325818803042-fig1.jpeg)
Cost Implications of Reactive Versus Prospective Testing for Dihydropyrimidine Dehydrogenase Deficiency in Patients With Colorectal Cancer: A Single-Institution Experience - Con Murphy, Stephen Byrne, Gul Ahmed, Andrew Kenny, James Gallagher, Harry Harvey,
![Pharmaceutics | Free Full-Text | DPYD and Fluorouracil-Based Chemotherapy: Mini Review and Case Report Pharmaceutics | Free Full-Text | DPYD and Fluorouracil-Based Chemotherapy: Mini Review and Case Report](https://www.mdpi.com/pharmaceutics/pharmaceutics-11-00199/article_deploy/html/images/pharmaceutics-11-00199-g001.png)
Pharmaceutics | Free Full-Text | DPYD and Fluorouracil-Based Chemotherapy: Mini Review and Case Report
![Figure 1 from Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)- related toxicity compared Figure 1 from Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)- related toxicity compared](https://d3i71xaburhd42.cloudfront.net/8d68e4ec8e7c85f1c1e4edcd5ff215ec925fe92c/3-Figure1-1.png)
Figure 1 from Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)- related toxicity compared
![Regulation of human dihydropyrimidine dehydrogenase: implications in the pharmacogenetics of 5-FU-based chemotherapy | Pharmacogenomics Regulation of human dihydropyrimidine dehydrogenase: implications in the pharmacogenetics of 5-FU-based chemotherapy | Pharmacogenomics](https://www.futuremedicine.com/cms/10.2217/14622416.8.3.257/asset/images/medium/graphic4.gif)
Regulation of human dihydropyrimidine dehydrogenase: implications in the pharmacogenetics of 5-FU-based chemotherapy | Pharmacogenomics
![Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G>A and a large intragenic inversion in DPYD spanning intron 8 to intron 12 - Kuilenburg - Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G>A and a large intragenic inversion in DPYD spanning intron 8 to intron 12 - Kuilenburg -](https://onlinelibrary.wiley.com/cms/asset/7e21f7e2-173a-4c37-96ce-9d191b36bb2b/humu23538-fig-0001-m.jpg)
Genome sequencing reveals a novel genetic mechanism underlying dihydropyrimidine dehydrogenase deficiency: A novel missense variant c.1700G>A and a large intragenic inversion in DPYD spanning intron 8 to intron 12 - Kuilenburg -
![Cancers | Free Full-Text | Testing for Dihydropyrimidine Dehydrogenase Deficiency to Individualize 5-Fluorouracil Therapy Cancers | Free Full-Text | Testing for Dihydropyrimidine Dehydrogenase Deficiency to Individualize 5-Fluorouracil Therapy](https://www.mdpi.com/cancers/cancers-14-03207/article_deploy/html/images/cancers-14-03207-g001-550.jpg)
Cancers | Free Full-Text | Testing for Dihydropyrimidine Dehydrogenase Deficiency to Individualize 5-Fluorouracil Therapy
![Treating patients with dihydropyrimidine dehydrogenase (DPD) deficiency with fluoropyrimidine chemotherapy since the onset of routine prospective testing—The experience of a large oncology center in the United Kingdom - ScienceDirect Treating patients with dihydropyrimidine dehydrogenase (DPD) deficiency with fluoropyrimidine chemotherapy since the onset of routine prospective testing—The experience of a large oncology center in the United Kingdom - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0093775421000749-gr1.jpg)
Treating patients with dihydropyrimidine dehydrogenase (DPD) deficiency with fluoropyrimidine chemotherapy since the onset of routine prospective testing—The experience of a large oncology center in the United Kingdom - ScienceDirect
![Evolution of Dihydropyrimidine Dehydrogenase Diagnostic Testing in a Single Center during an 8-Year Period of Time - ScienceDirect Evolution of Dihydropyrimidine Dehydrogenase Diagnostic Testing in a Single Center during an 8-Year Period of Time - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0011393X17300760-gr1.jpg)
Evolution of Dihydropyrimidine Dehydrogenase Diagnostic Testing in a Single Center during an 8-Year Period of Time - ScienceDirect
![DPYD genotype-guided dose individualization to improve patient safety of fluoropyrimidine therapy: call for a drug label update - Annals of Oncology DPYD genotype-guided dose individualization to improve patient safety of fluoropyrimidine therapy: call for a drug label update - Annals of Oncology](https://www.annalsofoncology.org/cms/asset/fe71302f-42fb-418c-bb43-94e239cbc26f/gr1.jpg)
DPYD genotype-guided dose individualization to improve patient safety of fluoropyrimidine therapy: call for a drug label update - Annals of Oncology
![Capecitabine-Induced Severe Toxicity Secondary to DPD Deficiency and Successful Treatment with Low Dose 5-Fluorouracil | SpringerLink Capecitabine-Induced Severe Toxicity Secondary to DPD Deficiency and Successful Treatment with Low Dose 5-Fluorouracil | SpringerLink](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs12029-015-9797-x/MediaObjects/12029_2015_9797_Fig1_HTML.gif)
Capecitabine-Induced Severe Toxicity Secondary to DPD Deficiency and Successful Treatment with Low Dose 5-Fluorouracil | SpringerLink
![Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity | Pharmacogenomics Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity | Pharmacogenomics](https://www.futuremedicine.com/cms/10.2217/pgs.11.72/asset/images/medium/figure1.gif)
Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity | Pharmacogenomics
![Issues and limitations of available biomarkers for fluoropyrimidine-based chemotherapy toxicity, a narrative review of the literature - ESMO Open Issues and limitations of available biomarkers for fluoropyrimidine-based chemotherapy toxicity, a narrative review of the literature - ESMO Open](https://www.esmoopen.com/cms/asset/abad0456-42a8-41a4-bdfd-29d1a21beff0/gr1.jpg)
Issues and limitations of available biomarkers for fluoropyrimidine-based chemotherapy toxicity, a narrative review of the literature - ESMO Open
![DPD-dependent inactivation of 5-FU and effects of DPD deficiency. For... | Download Scientific Diagram DPD-dependent inactivation of 5-FU and effects of DPD deficiency. For... | Download Scientific Diagram](https://www.researchgate.net/publication/233825437/figure/fig2/AS:202635266269192@1425323420768/DPD-dependent-inactivation-of-5-FU-and-effects-of-DPD-deficiency-For-abbreviations-see.png)